| Holiday | Date |
| New Year’s Day | Friday, December 31, 2021 |
| Martin Luther King Jr. Day | Monday, January 17 |
| Guam History & Chamorro Heritage Day | Monday, March 7 |
| Memorial Day | Monday, May 30 |
| Independence Day | Monday, July 4 |
| Liberation Day | Thursday, July 21 |
| Labor Day | Monday, September 7 |
| All Souls’ Day | Wednesday, November 2 |
| Veteran’s Day | Friday, November 11 |
| Thanksgiving Day | Thursday, November 24 |
| Our Lady of Camarin Day | Thursday, December 8 |
| Christmas Day | Monday, December 25 |